Related article: rapidly. The drug must not be confused with Ethylen bromid (C 2 H 4 Cl2), which is very poisonous. Bromoform (CHBr 3 ) is not sufficiently volatile to be of use as an anesthetic. It is employed as an antispasmodic in whooping cough, but is of very doubtful value (0.2 c.c.~3 minims, dropped on sugar. Practically insoluble in water, soluble in alcohol). Carbon tetrachlorid ("Tetra," CCU) is used as a non-explosive fat-solvent, and for drying the hair in shampooing. The vapor has given rise to serious poisoning (J.A.M.A., 1909, vol., 53, p. 726). Waller and Velay, 1909, state that it is more poisonous than chloroform. Lehmann, 1911 (who also investigated other aliphatic chlorin derivatives) found the vapor narcotic, but not excessively toxic. Industrial poisoning in rubber factories is described by Hamilton, 1915. Carbon Disulphid (CS 2 ). This very volatile Purchase Motilium Online fluid has a toxicologic importance, from its extensive use in the arts, particularly in the rubber industry (Stadelmann, 1896; A. Hamilton, 1915). Acute Poisoning Cheap Motilium is quite rare and produces effects similar to those of chloroform. Chronic Poisoning is the Order Motilium Online more common. The symptoms may not appear for several weeks and then develop quite slowly so that several stages may be distinguished. The effects have a pathological basis in irritative changes throughout the body. The symptoms begin with disturbed sensation (headache, formication, vertigo, etc.) and gastro-intestinal catarrh. In the second stage there is irritability, excitement, hysterical manifestations, etc., and signs of marasmus. The third stage shows central paralytic, or epileptic features, and. peripheral neurites. Ataxiahas been reported. The maras- mus is pronounced. Degenerative histologic changes are found in blood (hemolysis, leucocytosis, anemia; no methemoglobin formation), nerve cells and dendrites, liver (vacuolization), kidneys, and lungs. Death does not occur until very late. (A more extensive description is given Motilium Imodium on page 461 of the first edition.) The fluid or vapor causes conjunctivitis and other local inflammatory changes in the eye. Continuous exposure, even to small quantities, may produce a toxic blindness, similar to that produced by tobacco (Haas and Heim, 1911). PREPARATIONS ANESTHETICS *Chloroformum (Chlorof.), U.S.P., B.P.; Chloroform. Contains at least 99 per cent. CHCh; and 0.6 to i per cent, of alcohol. Heavy, colorless volatile liquid; boils at 60 to 6iC. Characteristic odor, sweet hot taste. Not inflammable. Slightly sol. in water (i : 210); freely miscible with ale., eth., etc. Dose, 0.3 c.c., Motilium Tablets 10mg 5 minims, U.S. P.; 0.06 to 0.3 c.c., i to 5 minims, B.P. Maximal dose, 0.5 c.c., 8 minims. *Aq. Chlorof., U.S. P., B.P. A saturated watery solution; 0.25 per cent., B.P. Used as hypnotic and flavor. Dose, 15 c.c., 4 drams, U.S. P. *Linimentum Chlorof ormi (Lin. Chlorof.), U.S.P. 30 per cent, of Chloroform in soap liniment. 590 MANUAL OF PHARMACOLOGY *Lin. Chlorof., B.P. Equal parts of chloroform and camphor liniment. *Sp. Chlorof., U.S.P., B.P. 6 per cent., U.S.P.; 5 per cent., B.P. Dose, z c.c., 30 minims, U.S.P.; 0.3 to 1.2 c.c., 5 to 20 minims, repeated; single, 2 to 2.5 c.c., 30 to 40 minims, B.P. (Tr. Chlorof. el Morph. Co., B.P. See Index.) Bromoformum (Bromof.), U.S.P., CHBr 3 . A heavy liquid, resembling chloroform. Slightly sol. in water; miscible with ale., chlorof., eth., and fixed or volatile oils. Slightly volatile, not inflammable. Dose, 0.2 c.c., 3 minims, U.S. P. (maximal, 0.5 c.c., 8 Motilium Oral Suspension minims), on sugar or dissolved in alcohol and glycerin. Used in pertussis, but probably without value. Side actions, Seifert, Nebenwirk., 1915, Motilium Generic Name p. 116. Carbon Disulphidum, B.P., CSz. *Mther, U.S.P., B.P.; /Ether Pur., B.P.; Ether (Sulphuric Ether) .Contains about 96 per cent, of ethyl oxid, (C 2 H5) 2 O, and about 4 per cent, of alcohol. Light volatile liquid. Sp. gr., 0.713 to 0.716, U.S. P.; 0.720 B.P. Boils at 3SC. Characteristic odor. Highly inflammable; vapors explosive. Sol. in water (i : 12) and in all propor- tions of ale. Dose, i c.c., 15 minims, U.S. P.; i to 2 c.c., 15 to 30 minims repeated; single, 3 to 4 c.c., 45 to 60 minims, B.P. Ether for anesthesia is to be dispensed only in small, well-closed containers and is not to be used as an anesthetic after the original container has been opened twenty-four hours. *Spiritus jEtherls (Sp. ^Ether.), U.S. P., B.P. (Hoffmann's Drops). 33 per cent, in alcohol. Dose, 4 c.c., i dram, U.S.P.; 1.2 to 2.5 c.c., 20 to 40 minims repeated; single, 4 to 6 c.c., 60 to 90 minims, Buy Cheap Motilium B.P. Sp. Mtheris Co., "Hoffmann's Anodyne," is an antiquated preparation of about the same strength and dose as the spiritus, containing additional ethereal products ("ethereal oil"). &ther Aceticus GEth. Acet.), B.P., C2HBC2H 3 O 2 . Dose, i to 2 c.c., 15 to 30 minims, repeated; single, 3 to 4 c.c., 45 to 60 minims, B.P. *Mthylis Chloridum (/Ethyl. Chlor.), U.S.P.; Ethyl Chlor., B.P. (Monochlor-ethane), CzHsCl. Colorless, extremely volatile liquid, of sharp, sweet taste, and peculiar odor. Inflammable. Boiling-point, 12 to i3C. Sparingly sol. in water, readily in ale. or eth. Dispensed in special glass or metal tubes. Used for freezing and for general anesthesia. Ethyl Bromid, C2H 5 Br. General properties resemble the preceding. Boiling- point, 38 to 4OC. Should be protected from light and heat. Used for short general anesthesia. ALIPHATIC HYPNOTICS Sleep is one of the earlier phenomena of light narcosis, and can there- fore be induced by small doses of any of the aliphatic narcotics. With many of these, however, the hypnotic stage is too brief, passes too easily into general anesthesia, or is complicated by undesirable side actions, stimulation, local irritation, etc. Desirable Features. The usefulness of a hypnotic depends upon Motilium 30 Mg the following qual- ities : Its action must be fairly prompt and lasting, so that the hypnotic effect will per- sist for some hours. Very volatile or easily decomposable substances are therefore excluded. A good somnifacient must produce the maximum hypnotic action, with the least depression of the medullary centers. It must not possess an odor or taste which would preclude its employment; and it must not irritate the stomach. Preparations which are insoluble in water, but which are nevertheless absorbed, are valuable because they are nearly tasteless, and because their action is apt to be more lasting. A soluble compound which could be used hypodermically would be very useful, but all the ali- phatic narcotics Motilium Uk are either too irritant or insoluble.